Professor Zeppenfeld was born in Werl/Germany. After having passed the Abitur (higher education entrance qualification in Germany), he studied computer sciences with mathematics as a minor subject at the University of Paderborn. Afterwards, he was employed as scientific assistant at Osnabrück University, where he also earned his doctorate. Subsequently working as a senior consultant for Capgemini (formerly: sd&m – software design & management AG), Professor Zeppenfeld was in various projects responsible for the holistic development of individual software solutions for key account customers.
In 1997, he accepted the position as a professor of computer sciences at the University of Applied Sciences and Arts in Dortmund/Germany, where he was appointed vice dean of the department in 1999, before being dean from 2005 to 2009. In this function, he helped to determine the orientation of the computer science department. In 2009, the Ministry of Science in North Rhine-Westphalia appointed Professor Zeppenfeld as founding president of Hamm-Lippstadt University of Applied Sciences. His second term as university president lasts until 2021. Since 2021 he is back as a teaching and research professor in the fields of practical computer science and software engineering at the University of Applied Sciences and Arts in Dortmund/Germany.
Besides his activities as a university professor, he also acted as a scientific director and as a chairman of the supervisory board in different companies and has written several scientific textbooks. He is also a member of an international jury panel for the annual Hamdan Bin Mohammad Award for Smart Government in Dubai since 2014.
Since October 2021, Professor Zeppenfeld was awarded as a Lifetime Fellow in the WTUN (World Technology Universities Network).